Less food initiates less cholesterol from the liver going into to the blood stream. Less fatty food is less triglycerides in the blood stream. There has to be enough HDL-High Density Lipid Cholesterol and other lipid proteins and vitamins dissolved in the blood to attach to triglycerides so plaque or clots will be kept from forming inside blood vessel walls.
Low Density Lipid-LDL Cholesterol can become part of the plaque. Usually the ratio of LDL to HDL is genetic. Some Statins leave HDL along and lock up LDL. Lipitor may reduce both which is important in Heart Rate Recovery (after a stress test).
http://care.diabetesjournals.org/content/27/4/936.full
Exercise after eating can lower blood sugar therefore insulin. The more fat and sugar in the blood the more Cholesterol and Insulin.
Insulin Resistance is caused by inflammation of persistent plaque molecules present in the blood stream as they are attached to the wall of the blood vessels and signaling that they need to be metabolized.
Insulin Resistance causes Type 2 Diabetes at the site of the cell membrane and in the cell. That is another story. Feel free to look into how a cell opens up to receive glucose and how sugar is needed to produce 34 ATP Molecules. ATP provided the energy to open and close and move the cell organelles and molecules.
In my opinion, exercise and less food, trans-fats and high density saturated fat will lower the bad compounds. You must have enough cholesterol to dissolve fat and enough fat to bond with cholesterol. Having just enough is the key component.