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Boudica the Lyoness

(2,899 posts)
49. Vit D can be dangerous. It has been for me.
Fri Jan 24, 2014, 11:46 PM
Jan 2014

I avoid the sun and all foods with added Vit D. I have a deadly dysfunction of vitamin D metabolism. The 'regular' 25D (vitamin D) test your doctor gives you, can be low, but your 1,25D might be high. Like mine is. Get tested for 1,25D if you are bound and determined to take supplements.

Please read this;

High Levels of Active 1,25-Dihydroxyvitamin D Despite Low Levels of the 25-Hydroxyvitamin D Precursor - Implications of Dysregulated Vitamin D for Diagnosis and Treatment of Chronic Disease

Authors: J. C. Waterhouse , Trevor G. Marshall, Belinda Fenter, Meg Mangin and Greg Blaney (The Stillpoint Project, Vancouver, Canada)

Abstract:
The active secosteroid hormone 1,25-dihydroxyvitamin-D (1,25D) often reaches excessive levels in normocalcemic patients suffering from chronic Th1 inflammatory illnesses, including sarcoidosis and rheumatoid arthritis. This is due to unregulated production of 1,25D in the mitochondria of activated macrophages. Phagocytic cells parasitized by cell wall deficient (CWD) L-forms of bacteria drive this dysfunction of vitamin D metabolism. The paracrine levels of 1,25D rise and the level of substrate 25-D falls. If studies measure only the 25D precursor, a low 25D may be misinterpreted as indicating the patient requires vitamin D supplementation. Our data show that active 1,25D hormone may be elevated, even with a low level of 25D substrate because of the inflamed macrophages’ hyperactive conversion to the active hormone. In sarcoidosis, for example, this dysregulated vitamin D conversion can mean that even a moderate intake of vitamin D through ingestion or solar exposure can cause the 1,25D hormone to become high enough to stimulate osteoclastic action, and bone resorption. Data presented here suggest that this extra-renal synthesis of 1,25D is more widespread than previously thought and because it leads to vitamin D hypersensitivity, has important implications for research, diagnosis and treatment of chronic disease..

More here;

https://www.novapublishers.com/catalog/product_info.php?products_id=5380

Recommendations

0 members have recommended this reply (displayed in chronological order):

So at my next physical I should take this to my doctor snooper2 Jan 2014 #1
I contacted my doctor about the recent AMA re-definition of high blood pressure IDemo Jan 2014 #2
I don't think it was Chuuku Davis Jan 2014 #53
It was the AMA IDemo Jan 2014 #57
Doesn't follow that you are not actually low on D3... hlthe2b Jan 2014 #3
This is about people taking vitamin D that aren't deficient. tammywammy Jan 2014 #9
Not entirely frazzled Jan 2014 #15
I'll take that 15%, thank you. djean111 Jan 2014 #4
Their outrage over woo has blinded them to what woo is. Rex Jan 2014 #16
Yes! If we say that taking vitamin D reduces fractures by 15%, then we are saying the same thing, Squinch Jan 2014 #29
That's what a doctor/researcher was saying on tv tonight laundry_queen Jan 2014 #52
Odd then dipsydoodle Jan 2014 #5
This is not about people that are deficient. tammywammy Jan 2014 #7
You reject it if you don't need it. dipsydoodle Jan 2014 #17
No. There are 4 fat soluble vitamins, K, A, D and E AngryAmish Jan 2014 #39
Dipsy, please read my post below. Boudica the Lyoness Jan 2014 #50
Don't tell that to the woo crowd. Vashta Nerada Jan 2014 #6
Unless . . . JustAnotherGen Jan 2014 #8
vit D bloodwork cost me $200 to find out I'm deficient - $2.34 cost of 3/mos Vit D nashville_brook Jan 2014 #10
Ahh JustAnotherGen Jan 2014 #14
since unused vitamin D is just flushed out, I'm skipping the bloodwork from now on nashville_brook Jan 2014 #56
vitamin D is a fat soluble vitamin, it is not "flushed out" etherealtruth Jan 2014 #60
JAG, what is A.S.? Number23 Jan 2014 #23
Ankylosing Spondylitis JustAnotherGen Jan 2014 #24
Dh has this too MissB Jan 2014 #26
Feel free JustAnotherGen Jan 2014 #31
Creaky joints are like my speciality Number23 Jan 2014 #34
I'm okay JustAnotherGen Jan 2014 #40
Oh my goodness, I had no idea Number23 Jan 2014 #41
Many thanks for all of it JustAnotherGen Jan 2014 #45
That doesn't leave us many other options during the Winter. tridim Jan 2014 #11
DU Rec... SidDithers Jan 2014 #12
Wait... what? DeadLetterOffice Jan 2014 #13
The question is, 15% of WHAT. frazzled Jan 2014 #19
Wow that some special kinda stupid they're teaching a MedU Biostatics 101. GeorgeGist Jan 2014 #27
Um, no frazzled Jan 2014 #28
You're quite right... DeadLetterOffice Jan 2014 #32
Supplements help when you have a deficiency. If you aren't deficient in something, you don't... phleshdef Jan 2014 #18
Mushroom soup-esp in winter... marions ghost Jan 2014 #20
How big was the study? flamingdem Jan 2014 #21
I long ago decied that there arew so many conflicting claims and studies about food that.... Armstead Jan 2014 #22
15% is better than most big pharma drugs. GeorgeGist Jan 2014 #25
Unless you have a vitamin D deficiency Dollface Jan 2014 #30
The end of the article links to a Harvard article think Jan 2014 #33
Thanks! pnwmom Jan 2014 #35
yw :) Just noticed that there is also a link think Jan 2014 #37
I'm wondering why some people are so eager to push the meme that supplements are worthless pnwmom Jan 2014 #38
Exactly! n/t Yo_Mama Jan 2014 #44
I can attest to that. RebelOne Jan 2014 #47
I have a b-12 deficiency, but that doesn't mean everyone should get the shots. pnwmom Jan 2014 #48
I take the shots for B6, B12 and Thiamine siligut Jan 2014 #54
Well ... my level was 13 the last time they tested in 2013 tandot Jan 2014 #51
Except the study doesn't apply to people with low blood levels, people who are actively pnwmom Jan 2014 #36
What a bunch of BS Matariki Jan 2014 #42
love hearing that greymattermom Jan 2014 #58
Interesting! Is there an increase in people suffering migraines? Matariki Jan 2014 #59
Of course it is, a certain group here always pushes FUD and hides behind Rex Jan 2014 #61
If you are really low in Vitamin D they definitely do Yo_Mama Jan 2014 #43
I hardly think this study takes chronic low D into account. Jasana Jan 2014 #46
Vit D can be dangerous. It has been for me. Boudica the Lyoness Jan 2014 #49
I saw your note above. dipsydoodle Jan 2014 #55
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