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http://scienceblogs.com/erv/2014/02/24/gmo_virus_vs_b_cell_acute_lymphoblastic_leukemia/
Science is doing amazing work with GMO viruses, using them to attack specific disease cells. Not all GMO is bad.
Sid
GMO virus vs B-Cell Acute Lymphoblastic Leukemia: Why is this not a standard therapy yet??
WHY IS THIS NOT STANDARD THERAPY YET?
Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
I wrote about this last year:
‘Dismal prognosis’ with leukemia? Nothing a GMO virus cant fix.
In the previous study, scientists took cytotoxic T-cells from five B-ALL patients, and infected them with a genetically modified virus. This GMO virus had a genome that essentially contained a ‘cheat sheet’ for teaching those CTLs how to kill B-ALL cancer cells. Four out of the five B-ALL patients recovered enough that they could get a bone marrow transplant.
In this new paper, they treated another 11 patients.
As per the current standard of care for adults with relapsed or refractory B-ALL, the initial primary aim of therapy is to reinduce a CR (8–10). This, in turn, renders the patient eligible for an allo-SCT, which is, at present, the only therapeutic modality with curative potential.
This means, they need to get the patient healthy enough for a bone marrow transplant. *That* is what ‘cures’ the cancer, not chemo, not radiation, not GMO viruses.
With standard ‘salvage chemotherapy’, 30% respond well, and 5% respond well enough to get a bone marrow transplant.
With ‘salvage chemotherapy’ and this GMO virus therapy, 88% responded well, and 44% were able to get a bone marrow transplant.
WHY IS THIS NOT STANDARD THERAPY YET?
Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
I wrote about this last year:
‘Dismal prognosis’ with leukemia? Nothing a GMO virus cant fix.
In the previous study, scientists took cytotoxic T-cells from five B-ALL patients, and infected them with a genetically modified virus. This GMO virus had a genome that essentially contained a ‘cheat sheet’ for teaching those CTLs how to kill B-ALL cancer cells. Four out of the five B-ALL patients recovered enough that they could get a bone marrow transplant.
In this new paper, they treated another 11 patients.
As per the current standard of care for adults with relapsed or refractory B-ALL, the initial primary aim of therapy is to reinduce a CR (8–10). This, in turn, renders the patient eligible for an allo-SCT, which is, at present, the only therapeutic modality with curative potential.
This means, they need to get the patient healthy enough for a bone marrow transplant. *That* is what ‘cures’ the cancer, not chemo, not radiation, not GMO viruses.
With standard ‘salvage chemotherapy’, 30% respond well, and 5% respond well enough to get a bone marrow transplant.
With ‘salvage chemotherapy’ and this GMO virus therapy, 88% responded well, and 44% were able to get a bone marrow transplant.
Science is doing amazing work with GMO viruses, using them to attack specific disease cells. Not all GMO is bad.
Sid
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