General Discussion
In reply to the discussion: Either you believe in the scientific method or you don't [View all]Avalux
(35,015 posts)I'm not sure you do either. Drug/device/biologic development is far from perfect, but if we want to be able to cure and treat diseases, disorders, injuries, etc., a certain amount of risk is inherent. Clinical studies are intended to show that the benefit outweighs the risk, but not all 'studies' are created equal.
Clinical evidence includes lit review icase series, meta-analysis, retrospective study, observational study, and finally a randomized controlled study. The level of risk determines the type of study (or studies) needed to support the hypothesis. Drug studies always require randomized controlled tirlals, but it's impossible to know everything before approval.
Ongoing clinical research and adverse event reporting of approved drugs, devices and biologics are why we sometimes have reversals. And that's a GOOD thing.