1. Climate change. Anything and everything that will make even a minor contribution to addressing it, although some major action would be nice.
2. Protecting natural resources as much as possible. The human population has blown past the planet's comfortable carrying capacity and we'd better start preserving every bit of at least quasi-wilderness that we can, while we still can.
3. Reproductive rights, particularly the right to not reproduce. (in addition to the basic human rights aspect, see items 1 and 2). Plenty of people will still be perfectly happy to provide more social security payer-inners. Or we could start welcoming immigrants like that tall statue thingy at Ellis Island kind of says we do. Let's stop forcing people to have kids they're not ready and happy to care for.
4. Reduce spending on incarceration and ruining lives in the Drug War.
5. Get money out of politics. (yeah, right) Anyway try to find some way of limiting big-dollar campaign contributions, or at least requiring transparency / disclosure of large donors.
6. Figure out how to make it easier for sole-provider primary practice docs (and other small providers) to navigate the EMR software swamp. This seems to be a real hardship for the small practices. As if they don't have enough to deal with besides taking care of patients.
7. Figure out how to entice more bright young people to choose primary care medicine as their career. And especially to help out in underserved areas.
99. (a small but meaningful thing) restore parity for mass transit commuter tax break with parking. Last budget they failed to re-authorize the increased mass transit pre-tax monthly maximum and it fell back to 130 (which is less than a zone 2 rail pass costs in Philly). Parking is 200 or so. It's bullshit that parking a private car should get a bigger tax break than taking mass transit. (Refer also to #1 above.)
.... and so many more but that's a start. 
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