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True Earthling

(832 posts)
Thu Jun 30, 2016, 10:41 AM Jun 2016

Marijuana compound removes toxic Alzheimer's protein from the brain [View all]

Last edited Thu Jun 30, 2016, 12:30 PM - Edit history (1)

Scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer's disease.

https://www.sciencedaily.com/releases/2016/06/160629095609.htm

"Inflammation within the brain is a major component of the damage associated with Alzheimer's disease, but it has always been assumed that this response was coming from immune-like cells in the brain, not the nerve cells themselves," says Antonio Currais, a postdoctoral researcher in Schubert's laboratory and first author of the paper. "When we were able to identify the molecular basis of the inflammatory response to amyloid beta, it became clear that THC-like compounds that the nerve cells make themselves may be involved in protecting the cells from dying."

Brain cells have switches known as receptors that can be activated by endocannabinoids, a class of lipid molecules made by the body that are used for intercellular signaling in the brain. The psychoactive effects of marijuana are caused by THC, a molecule similar in activity to endocannabinoids that can activate the same receptors. Physical activity results in the production of endocannabinoids and some studies have shown that exercise may slow the progression of Alzheimer's disease.

Schubert emphasized that his team's findings were conducted in exploratory laboratory models, and that the use of THC-like compounds as a therapy would need to be tested in clinical trials.


edit - some additional info.

A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562334/

Compared to currently approved drugs prescribed for the treatment of Alzheimer's disease, THC is a considerably superior inhibitor of Abeta aggregation, and this study provides a previously unrecognized molecular mechanism through which cannabinoid molecules may directly impact the progression of this debilitating disease.


J147 was mentioned in the article. J147 is a derivative of curcumin...

http://www.mybraintest.org/2016/01/curcumin-and-brain-health/
Researchers at the Salk Institute in La Jolla, California working on an experimental drug for Alzheimer’s disease have made a happy discovery that the compound also appears to have some generalized anti-aging properties.

Known as J147, the drug is based on a specialized formation of curcumin, the spice used in curry. Curcumin is a potent anti-inflammatory molecule that can cross the blood-brain barrier.


Salk J147 study...
https://docs.google.com/viewer?url=http%3A%2F%2Fwww.impactaging.com%2Fpapers%2Fv7%2Fn11%2Fpdf%2F100838.pdf
81 replies = new reply since forum marked as read
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EXCELLENT! Faux pas Jun 2016 #1
The more studies that come out... SkyDaddy7 Jun 2016 #26
It absurdly crazy! Faux pas Jun 2016 #28
I'm so sorry... SkyDaddy7 Jun 2016 #41
I'm sorry for you too Faux pas Jul 2016 #75
Yeah, you were "lucky" SkyDaddy7 Jul 2016 #79
Yikes SkyDaddy7 Faux pas Jul 2016 #80
My mother did too lunatica Jun 2016 #56
I've had the same thoughts. Scary stuff. bettyellen Jul 2016 #70
We don't have it yet! Faux pas Jul 2016 #74
absurd? try CRIMINAL Locrian Jul 2016 #67
+1 nt. SkyDaddy7 Jul 2016 #78
Good news! Arkansas Granny Jun 2016 #2
In other news, Marijuana removes body from mind! nolabels Jun 2016 #29
Well, I think we've known that for a long time. Arkansas Granny Jun 2016 #31
Lol. This sounds very hopeful. Hortensis Jun 2016 #44
Hoping for anything that stops this horrible disease! Silver_Witch Jun 2016 #3
Big Pharma will find a way to test, develop some outrageously priced AllyCat Jun 2016 #10
"Stay stoned, stay sane", I always say. Kip Humphrey Jun 2016 #4
Important news. Whether THC is the ultimate weapon or not it will advance research. . nt Bernardo de La Paz Jun 2016 #5
The dirty, fucking hippies were right again! Scuba Jun 2016 #6
Yeah, we were. dixiegrrrrl Jun 2016 #7
Just smoke weed every day - smoke two joints! It works every time! Elmer S. E. Dump Jun 2016 #43
Take one drug that gives you poor memory to avoid a disease that gives you poor memory.. dixiegrrrrl Jun 2016 #60
Read up on mj. It prevents many diseases, cancer, heart disease, diabetes... Elmer S. E. Dump Jul 2016 #72
You are correct about using the right strain jumptheshadow Jul 2016 #71
We hippies KNOW that we were right all along. RoccoR5955 Jun 2016 #16
Well that explains Willie Nelson. nt bemildred Jun 2016 #8
Of course, we can't test that. AllyCat Jun 2016 #9
The Weed's legal in Oregon. Come test it here. 99th_Monkey Jun 2016 #21
I applaud the states trying to inject some reason into AllyCat Jun 2016 #33
Nevertheless, legalization is working. Warren DeMontague Jun 2016 #57
I have been testing it for over 50 years now. WHEN CRABS ROAR Jun 2016 #42
I applaud your willingness to put your beliefs to the test! :) Akamai Jul 2016 #68
Give me a fricking break! Elmer S. E. Dump Jun 2016 #45
Did you read my post or only the first line? AllyCat Jun 2016 #48
No, I read it and agree with it! I guess I just broke into a happy dance. Elmer S. E. Dump Jun 2016 #58
Oh! AllyCat Jul 2016 #63
THC is already proven better Rx for Alzheimer's than ANY currently available meds TheSarcastinator Jun 2016 #11
Wow, being a pot head might have more benefits other than good sleep! lark Jun 2016 #22
Well it paid ALL the bills from 1989-2014 chknltl Jun 2016 #32
Good thing it is illegal...well in some states. Rex Jun 2016 #12
Good thing the Democratic platform intends to keep it illegal in the face of MORE evidence! phazed0 Jun 2016 #13
Careful! We are not allowed to ask for reason AllyCat Jun 2016 #34
Been smoking daily since 1972 and in EXCELLENT health! Elmer S. E. Dump Jun 2016 #14
1964 for me................. n-t Ernesto Jun 2016 #17
Then you must REALLY be healthy!! Elmer S. E. Dump Jun 2016 #40
Another example of how the "war on drugs" is an abject failure. Moostache Jun 2016 #15
J147 is mentioned in the article.. J147 is a derivative of Curcumin True Earthling Jun 2016 #18
I HEART cumin! AllyCat Jun 2016 #35
curcumin is tumeric LWolf Jun 2016 #49
LOL! Yup! My mistake. AllyCat Jun 2016 #50
So do I. LWolf Jun 2016 #53
Well, all "curry powder" is, is a mix of spices, to include turmeric... MADem Jul 2016 #64
K & R nt Javaman Jun 2016 #19
Kicked and recommended. Uncle Joe Jun 2016 #20
K&R - The more we learn, the more idiotic we look making it illegal. LEGALIZE! nt 99th_Monkey Jun 2016 #23
If I didn't have to pass drug screens for work, I'd probably get high sometimes. Skeeter Barnes Jun 2016 #24
Just wow Politicub Jun 2016 #25
I'm glad someone is researching it IronLionZion Jun 2016 #27
K & R mountain grammy Jun 2016 #30
Really exciting news. Svafa Jun 2016 #36
The best university system in the word has to wait for approval from DEA to study weed. Eleanors38 Jun 2016 #37
Base on this story I will never get Alzheimers.... Playinghardball Jun 2016 #38
Me too! Elmer S. E. Dump Jun 2016 #47
KNR Lucinda Jun 2016 #39
"a progressive brain disorder that leads to memory loss" bluedigger Jun 2016 #46
Now if I could only rememberů dhill926 Jun 2016 #51
Post removed Post removed Jun 2016 #52
"The faces of marijuana addicts" Warren DeMontague Jun 2016 #54
Thank god we are still sticking millions of people in prison for smoking it! Warren DeMontague Jun 2016 #55
Are we talking about prevention here? fbc Jun 2016 #59
The thing that kills me is that this info isn't new. PoliticalMalcontent Jun 2016 #61
I wish this had come out 15 years ago. raven mad Jun 2016 #62
Good news since I have alzheimers in my family. Lunabell Jul 2016 #65
Slow down folks, remember we can't take big bold progess. mrr303am Jul 2016 #66
Yes! Incrementalism is best. Health care just needs tweaking nt Arazi Jul 2016 #81
My dear sister was diagnosed at age 50 as having Alzheimers. She passed 10 years later. So, I only downeastdaniel Jul 2016 #69
Someone once said that if aspirin were discovered today it would probably be tblue37 Jul 2016 #73
Great-isolate the compound and use it... apcalc Jul 2016 #76
They have known this since 2006... Ghost in the Machine Jul 2016 #77
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