The number one, first truly practical thing that we can to STOP this mess is

[VOX]

4. Taking the Senate would be a more attainable goal...

Just a few seats here and there, gaining a D majority in the Senate is highly do-able.

But right now, R's have a political power the strength of which hasn't been matched since 1928. And due to gerrymandering and a majority of states being ruled by R's, Congress is going to remain R for a long, long time. It's just not a realistic target at this time. Sure, win what can be won, but it will be uphill all the way-- Democrats have lost more than 60 House seats since 2010.
http://m.dailykos.com/story/2016/11/14/1598918/-Republicans-now-dominate-state-government-with-32-legislatures-and-33-governors
...Republicans control both chambers in 32 states, including 17 with veto-proof majorities. Those 32 states cover 61 percent of the U.S. population. Democrats, meanwhile, control the legislature in just 13 states, amounting to 28 percent of the country’s population; only five of those chambers have veto-proof majorities...

Where R's have state control, they can then gerrymander away to their heart's content. And that means an R lock on Congress. If you missed it, try to catch HBO's 4/09/17 edition of "Last Week Tonight With John Oliver." It has an excellent analysis of gerrymandering.