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longship

(40,416 posts)
62. The facts on ketogenic diets and cancer.
Sat Jul 22, 2017, 04:25 PM
Jul 2017

As I posted above, I am skeptical of this claim. Apparently, so are oncologists, like David Gorski.

Here's his summary of ketogenic diets.

Clearly, ketogenic diets are not ready for prime time as a treatment for cancer, either alone or in combination with conventional therapy. Unfortunately, that hasn’t stopped it from being touted by all manner of alternative cancer practitioners (i.e., quacks) and others as a cancer cure that “they” don’t want you to know about or saying things like, “…it’s nothing short of medical malpractice and negligence to fail to integrate this type of dietary strategy into a patient’s cancer treatment plan,” as Joe Mercola did. Dr. Seyfried himself has contributed to the hyperbole quite a bit as well. For example:

"These studies are all in combination with either radiation or chemotherapy. My preference is to start metabolic therapy with GBM (glioblastoma multiforme). This is a devastating type of brain cancer. Metabolic therapy with a restricted KD could be done with a few tumors where you know the conventional standard of care doesn’t work at all. You would choose those kinds of patients and do a clinical trial based on historical controls and see what the outcome would be and see if you could get some level of survival that would match or be better than the conventional standard of care."

Regular readers of SBM should know the problem with this sort of approach. No IRB worth its salt would approve such a trial because it would be ethically dubious, but, even worse, it would be ethically dubious and it wouldn’t really tell us anything unless those few patients either had near-miraculous responses or died very quickly. Anything else would simply tell us that the diet is probably doing no harm. More numbers would be needed, particularly if the comparison is to historical controls, to get even an inkling of whether there might be benefit. In that case, you might as well do a proper phase I/II clinical trial, which is what is happening.

(Snip links to current trials)

In other words, clinical data should be rolling in fairly soon, and that’s a good thing. In the meantime Dr. Seyfried and other advocates who so passionately believe that ketogenic diets will greatly help patients with brain cancer do no one any favors by claiming unequivocally that cancer is a metabolic disease and saying that ketogenic diets are more beneficial than chemotherapy for patients with brain tumors.


Much, much more at link.

Ketogenic diets for cancer -- hype vs science (At Science-Based Medicine Blog)

Apparently my skepticism is well placed. The studies cited in this thread are at best preliminary and apparently unblinded. (Not sure how one would blind somebody's diet, however.) As Dr. Gorski says, there are some stage I/II clinical trials in the works. So we may know the facts soon enough. And in conjunction with standard treatment, the diet at least seems to do no harm, although a few patients in the pilot trials seemingly could not tolerate it and dropped out, which should be a bit worrisome to folks promoting it. Then, there's the issue that a main proponent of ketogenic diets for cancer has associated with the utter quack Joseph Mercola.

My best to you all.

Recommendations

0 members have recommended this reply (displayed in chronological order):

Hate his politics, but he is no coward GulfCoast66 Jul 2017 #1
That's what Ted Kennedy did. I expect McCain to fight this, too. n/t pnwmom Jul 2017 #2
Hate his politics but he was decent in negating the woman in '08 who tried to paint O as a... brush Aug 2017 #76
This is a nasty disease peggysue2 Jul 2017 #3
It's supposed to be very rare and yet pnwmom Jul 2017 #4
We have a family friend peggysue2 Jul 2017 #11
It is awful, and I'm very sorry about your friend. pnwmom Jul 2017 #12
Thanks for the reply, pwnmom peggysue2 Jul 2017 #41
Keto for brain cancers Jannod Jul 2017 #45
Interesting peggysue2 Jul 2017 #47
Keto for brain cancers Jannod Jul 2017 #43
My father died of it spinbaby Jul 2017 #22
I'm very sorry, spinbaby. pnwmom Jul 2017 #23
Very rare? Wow. I myself know 5 people who died of this. nt Nay Jul 2017 #24
I lost my husband from this very same spartan61 Jul 2017 #30
My condolences. Jannod Jul 2017 #44
We did a brain biopsy 1 month ago on a 20-year old Horse with no Name Jul 2017 #5
No, not on anyone. But a 20 year old -- what a tragedy. n/t pnwmom Jul 2017 #6
It was tragic. Horse with no Name Jul 2017 #8
a ketigenic diet helps this soecific type of cancer. KewlKat Jul 2017 #7
It doesn't. nt Horse with no Name Jul 2017 #9
If you'd care to read about it here are a couple. Second article talks about why US doesnt trial KewlKat Jul 2017 #33
More evidence Jannod Jul 2017 #59
No. It doesn't. Please, no woo-woo here on this topic. longship Jul 2017 #10
As long as someone doesn't forgo standard treatments to try this, then why not? pnwmom Jul 2017 #15
No diet is a cure for cancer. longship Jul 2017 #17
There is no cure for glioblastoma period. That was not the claim. And if a patient with an incurable pnwmom Jul 2017 #19
Hint: Hope does not help with glioblastoma either. longship Jul 2017 #20
Hope is an ESSENTIAL element when facing glioblastoma. pnwmom Jul 2017 #25
+1000. nt ecstatic Jul 2017 #28
+1,000,000 former9thward Jul 2017 #52
You said "The only hope is to fight the battle with science and medicine" KewlKat Jul 2017 #31
Keto for glioblastomas Jannod Jul 2017 #46
There is evidence that starving cancer works Iwasthere Jul 2017 #55
Keto for brain cancers Jannod Jul 2017 #40
Thanks. Will review it. nt longship Jul 2017 #42
Keto for brain cancers Jannod Jul 2017 #60
I am very skeptical of this, but will consider it. longship Jul 2017 #61
Keto for brain cancer Jannod Jul 2017 #63
Sorry, the science is not exactly there, and anecdotal evidence does not count in science. longship Jul 2017 #64
Keto for brain cancers Jannod Aug 2017 #74
I'll stand by my posts. Keto diet for brain cancer is bunkum. longship Aug 2017 #75
Click here and learn. longship Jul 2017 #65
Jannod, read your own study conclusions. This has efficacy as Hortensis Jul 2017 #67
Keto for brain cancers Jannod Jul 2017 #69
There is no such thing as alternative medicine. longship Jul 2017 #68
Welcome to DU, Jannod! pnwmom Jul 2017 #54
My friend is using novocure and a keto diet Beaverhausen Jul 2017 #50
Thanks for mentioning this. I did a little reading and there are some interesting findings. Lucinda Jul 2017 #13
Wrong, just stop with the Dr. Mercola woo obamanut2012 Jul 2017 #21
Knowledge is power. What is dangerous is the orange man in our WH. KewlKat Jul 2017 #32
What is also dangerous is alternative medicine! longship Jul 2017 #66
Keto for brain cancers Jannod Jul 2017 #49
Keto works Jannod Jul 2017 #38
Not trying to nitpick... Docreed2003 Jul 2017 #51
KD used for glioma and glioblastoma. Read the study. Jannod Jul 2017 #56
Skepticism is good but also with Pharma Jannod Jul 2017 #57
Glioblastoma v glioma Jannod Jul 2017 #71
I'm aware of the grading and classification, thanks. Docreed2003 Jul 2017 #72
Glioma v gluoblastoma Jannod Jul 2017 #73
More evidence for keto Jannod Jul 2017 #58
Its a particularly nasty cancer. I wouldn't wish it upon anyone. Nailzberg Jul 2017 #14
I wish Senator McCain well in his recovery. Warren DeMontague Jul 2017 #16
There are promising new options being researched misanthrope Jul 2017 #18
Also Keto Diet Jannod Jul 2017 #39
my FIL died of this.. after they did the surgery he was actually worse.. samnsara Jul 2017 #26
It is unlikely that all of the tumor was removed which is why the survival rate is so low Gothmog Jul 2017 #27
I know 2 adults and one child who survived glioblastoma Justice Jul 2017 #29
Wow! An almost 10 year survivor. pnwmom Jul 2017 #36
I'll argue this crosses over into the realm of political discussion in a few areas: Warren DeMontague Jul 2017 #34
I know of a five men around me with the same diagnosis- bathroommonkey76 Jul 2017 #35
The obvious problem with your argument: LeftyMom Jul 2017 #37
Doctors say it this is a "rare" cancer bathroommonkey76 Jul 2017 #53
It's a terrible disease. I haven't liked McCain's political positions The Velveteen Ocelot Jul 2017 #48
The facts on ketogenic diets and cancer. longship Jul 2017 #62
"What treatments come next?" Nevernose Jul 2017 #70
Latest Discussions»General Discussion»The problem with glioblas...»Reply #62