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In reply to the discussion: The problem with glioblastoma is that completely removing all the visible tumor --as the surgeon did [View all]longship
(40,416 posts)62. The facts on ketogenic diets and cancer.
As I posted above, I am skeptical of this claim. Apparently, so are oncologists, like David Gorski.
Here's his summary of ketogenic diets.
Clearly, ketogenic diets are not ready for prime time as a treatment for cancer, either alone or in combination with conventional therapy. Unfortunately, that hasnt stopped it from being touted by all manner of alternative cancer practitioners (i.e., quacks) and others as a cancer cure that they dont want you to know about or saying things like, its nothing short of medical malpractice and negligence to fail to integrate this type of dietary strategy into a patients cancer treatment plan, as Joe Mercola did. Dr. Seyfried himself has contributed to the hyperbole quite a bit as well. For example:
"These studies are all in combination with either radiation or chemotherapy. My preference is to start metabolic therapy with GBM (glioblastoma multiforme). This is a devastating type of brain cancer. Metabolic therapy with a restricted KD could be done with a few tumors where you know the conventional standard of care doesnt work at all. You would choose those kinds of patients and do a clinical trial based on historical controls and see what the outcome would be and see if you could get some level of survival that would match or be better than the conventional standard of care."
Regular readers of SBM should know the problem with this sort of approach. No IRB worth its salt would approve such a trial because it would be ethically dubious, but, even worse, it would be ethically dubious and it wouldnt really tell us anything unless those few patients either had near-miraculous responses or died very quickly. Anything else would simply tell us that the diet is probably doing no harm. More numbers would be needed, particularly if the comparison is to historical controls, to get even an inkling of whether there might be benefit. In that case, you might as well do a proper phase I/II clinical trial, which is what is happening.
(Snip links to current trials)
In other words, clinical data should be rolling in fairly soon, and thats a good thing. In the meantime Dr. Seyfried and other advocates who so passionately believe that ketogenic diets will greatly help patients with brain cancer do no one any favors by claiming unequivocally that cancer is a metabolic disease and saying that ketogenic diets are more beneficial than chemotherapy for patients with brain tumors.
Much, much more at link.
Ketogenic diets for cancer -- hype vs science (At Science-Based Medicine Blog)
Apparently my skepticism is well placed. The studies cited in this thread are at best preliminary and apparently unblinded. (Not sure how one would blind somebody's diet, however.) As Dr. Gorski says, there are some stage I/II clinical trials in the works. So we may know the facts soon enough. And in conjunction with standard treatment, the diet at least seems to do no harm, although a few patients in the pilot trials seemingly could not tolerate it and dropped out, which should be a bit worrisome to folks promoting it. Then, there's the issue that a main proponent of ketogenic diets for cancer has associated with the utter quack Joseph Mercola.
My best to you all.
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The problem with glioblastoma is that completely removing all the visible tumor --as the surgeon did [View all]
pnwmom
Jul 2017
OP
Hate his politics but he was decent in negating the woman in '08 who tried to paint O as a...
brush
Aug 2017
#76
If you'd care to read about it here are a couple. Second article talks about why US doesnt trial
KewlKat
Jul 2017
#33
There is no cure for glioblastoma period. That was not the claim. And if a patient with an incurable
pnwmom
Jul 2017
#19
Sorry, the science is not exactly there, and anecdotal evidence does not count in science.
longship
Jul 2017
#64
Thanks for mentioning this. I did a little reading and there are some interesting findings.
Lucinda
Jul 2017
#13
It is unlikely that all of the tumor was removed which is why the survival rate is so low
Gothmog
Jul 2017
#27
I'll argue this crosses over into the realm of political discussion in a few areas:
Warren DeMontague
Jul 2017
#34
It's a terrible disease. I haven't liked McCain's political positions
The Velveteen Ocelot
Jul 2017
#48