Possible Alzheimer's Prevention Breakthrough Reported

[mahina]

45. I searched "pubmed, dementia, coffee,novels"

https://www.ncbi.nlm.nih.gov/pubmed/20182054


J Alzheimers Dis. 2010;20 Suppl 1:S167-74. doi: 10.3233/JAD-2010-1404.
Caffeine as a protective factor in dementia and Alzheimer's disease.

Eskelinen MH1, Kivipelto M.
Author information
Abstract
Caffeine has well-known short-term stimulating effects on central nervous system, but the long-term impacts on cognition have been less clear. Dementia and Alzheimer's disease (AD) are rapidly increasing public health problems in ageing populations and at the moment curative treatment is lacking. Thus, the putative protective effects of caffeine against dementia/AD are of great interest. Here, we discuss findings from the longitudinal epidemiological studies about caffeine/coffee/tea and dementia/AD/cognitive functioning with a special emphasis on our recent results from the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study. The findings of the previous studies are somewhat inconsistent, but most studies (3 out of 5) support coffee's favorable effects against cognitive decline, dementia or AD. In addition, two studies had combined coffee and tea drinking and indicated some positive effects on cognitive functioning. For tea drinking, protective effects against cognitive decline/dementia are still less evident. In the CAIDE study, coffee drinking of 3-5 cups per day at midlife was associated with a decreased risk of dementia/AD by about 65% at late-life. In conclusion, coffee drinking may be associated with a decreased risk of dementia/AD. This may be mediated by caffeine and/or other mechanisms like antioxidant capacity and increased insulin sensitivity. This finding might open possibilities for prevention or postponing the onset of dementia/AD.
PMID: 20182054 DOI: 10.3233/JAD-2010-1404
[Indexed for MEDLINE]
Share on FacebookShare on TwitterShare on Google+
Publication type, MeSH terms, Substances

https://www.ncbi.nlm.nih.gov/pubmed/29807456
Send to
Dementia (London). 2018 Jan 1:1471301218778398. doi: 10.1177/1471301218778398. [Epub ahead of print]
Dementia and detectives: Alzheimer's disease in crime fiction.

Orr DM1.
Author information
Abstract
Fictional representations of dementia have burgeoned in recent years, and scholars have amply explored their double-edged capacity to promote tragic perspectives or normalising images of 'living well' with the condition. Yet to date, there has been only sparse consideration of the treatment afforded dementia within the genre of crime fiction. Focusing on two novels, Emma Healey's Elizabeth is Missing and Alice LaPlante's Turn of Mind, this article considers what it means in relation to the ethics of representation that these authors choose to cast as their amateur detective narrators women who have dementia. Analysing how their narrative portrayals frame the experience of living with dementia, it becomes apparent that features of the crime genre inflect the meanings conveyed. While aspects of the novels may reinforce problem-based discourses around dementia, in other respects they may spur meaningful reflection about it among the large readership of this genre.
KEYWORDS:
Alzheimer’s disease; crime fiction; dementia; detective fiction; genre; literary gerontology; representation