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muriel_volestrangler

(106,236 posts)
11. This seems to say it affects how the genes are expressed
Fri Aug 2, 2013, 11:35 AM
Aug 2013

not the genes that you pass on to your children.

From the paper:

Previous studies have found that circulating immune cells show a systematic shift in basal gene expression profiles during extended periods of stress, threat, or uncertainty. This conserved transcriptional response to adversity (CTRA) is characterized by increased expression of genes involved in inflammation and decreased expression of genes involved in type I IFN antiviral responses. The CTRA transcriptional program likely evolved to help the immune system counter the changing patterns of microbial threat ancestrally associated with changing socioenvironmental conditions (e.g., increased risk of wound-related bacterial infection associated with experienced threat or social conflict vs. increased risk of socially mediated viral infection associated with affine social contact). However, in the very different environment of contemporary human society, chronic CTRA activation by social or symbolic threats may promote inflammation mediated cardiovascular, neurodegenerative, and neoplastic diseases and impair host resistance to viral infections. The present analysis used the CTRA gene expression profile as a high-dimensional molecular reference space in which to map the potentially distinct biological effects of hedonic and eudaimonic well-being.

www.unc.edu/peplab/publications/Fredrickson%202013%20PNAS.pdf


So I think this is saying that stress can make your immune system emphasise defence against wound infection, at the expense of other parts of your health; and that can also happen to 'hedonic' people, although they regard themselves as happy, not stressed.

Recommendations

0 members have recommended this reply (displayed in chronological order):

Crap! I'm the wrong kind of happy. alfredo Aug 2013 #1
Just find meaning in your hedonistic pursuits and you're good to go. SunSeeker Aug 2013 #5
I just have to channel RJ of Over the Hedge. alfredo Aug 2013 #12
Try Tantra and you can combine the two! kentauros Aug 2013 #15
Tantric Yoga, that was big back in the seventies. Liquor was quicker. alfredo Aug 2013 #16
Liquor MAY be quicker, kentauros Aug 2013 #17
I'll take a look. alfredo Aug 2013 #18
Gabrielle Anwar and Catherine Oxenberg will be doing a documentary bananas Aug 2013 #21
Oh that's cool! kentauros Aug 2013 #30
Interesting concept. silverweb Aug 2013 #2
Well, *MY* happiness affects the whole universe. delrem Aug 2013 #3
Well. if Momma ain't happy, none of this is gonna matter anyway... n/t jtuck004 Aug 2013 #4
Ha! alfredo Aug 2013 #13
True in this household! Keep me happy and things will go along swimmingly..... Nay Aug 2013 #26
K&R DeSwiss Aug 2013 #6
It's research. They'd have to define it or use commonly accepted definitions. Igel Aug 2013 #8
Aha! The biological mechanism of karma! Chemisse Aug 2013 #7
So a person gets a disease because they are being horribly abused for years...karma??? LiberalLoner Aug 2013 #10
I would hardly call abuse a source of hedonistic pleasure. Chemisse Aug 2013 #19
But it works both ways, right? LiberalLoner Aug 2013 #24
Perhaps you could elaborate. I'm just not getting it. Chemisse Aug 2013 #25
People have told me I have health problems due to having been abused as a kid. LiberalLoner Aug 2013 #27
No that certainly is NOT fair. Chemisse Aug 2013 #29
And what does unhappiness do marions ghost Aug 2013 #9
This seems to say it affects how the genes are expressed muriel_volestrangler Aug 2013 #11
The pursuit of thrills can be quite draining. alfredo Aug 2013 #14
Thanks, that's an important clarification. Jim Lane Aug 2013 #22
This is why I donate generously rucky Aug 2013 #20
Wait one minute. Is this article implying Lamarckism? ramparta Aug 2013 #23
Getting into someone's jeans can affect your happiness. westerebus Aug 2013 #28
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