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In reply to the discussion: Big change to make it harder for patients to get pain killers like Vicodin [View all]UglyGreed
(7,661 posts)weaned myself off of fentanyl since I was losing a lot of weigh due to appetite suppression, I did not go through any of those symptoms even after being on it for over two years. So perhaps chronic pain suffers react differently than those who are addicted and using these drugs to get high????
Fentanyl (also known as fentanil, brand names Sublimaze,[3] Actiq, Durogesic, Duragesic, Fentora, Matrifen, Haldid, Onsolis,[4] Instanyl,[5] Abstral,[6] Lazanda[7] and others[8]) is a potent, synthetic opioid analgesic with a rapid onset and short duration of action.[9] It is a strong agonist at the μ-opioid receptors. Historically it has been used to treat breakthrough pain and is commonly used in pre-procedures as a pain reliever as well as an anesthetic in combination with a benzodiazepine.
Fentanyl is approximately 50-100 times more potent than morphine.[10]
Fentanyl was first synthesized by Paul Janssen in 1960[11] following the medical inception of pethidine several years earlier. Janssen developed fentanyl by assaying analogues of the structurally related drug pethidine for opioid activity.[12] The widespread use of fentanyl triggered the production of fentanyl citrate (the salt formed by combining fentanyl and citric acid in a 1:1 stoichiometry),[13] which entered the clinical practice as a general anaesthetic under the trade name Sublimaze in the 1960s. Following this, many other fentanyl analogues were developed and introduced into medical practice, including sufentanil, alfentanil, remifentanil, and lofentanil.