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In reply to the discussion: Blacks have trouble clearing cervical cancer virus [View all]Liber-AL
(71 posts)44. Interesting thread. After a review I tend to agree with
bemildred. Her assessment is right in line with mine. Indeed, the USA is a genetic melting pot and has been for centuries. And this talk of "millions" of years in the development of specific haplogroupings seems nonsensical since all of those early hominid populations died out, leaving the world in the hands of Homo Sapiens Sapiens; who, BTW are thought to have emerged 280,000 years ago in East Africa.
Since ALL humans alive today are descendants of a mitochondrial Eve from that epochal population, it would appear that all of modern humanity started out with the same Haplogroup. I am reluctant to say "L," because I don't know what the environment of East Africa was 200,000 year ago. That factor is significant since environment is thought to be the catalyst in haplogroup mutations that deviated from the original (L?) groups as modern humans left Africa.
Complicating things further is the fact that there are two distinct sets of haplogroup markers:
one originating from a common Patrilineal ancestor and the other from the matrilineal side , each with a distinct
set of letters to denote degree of mutation. From the common ancestor's mTDNA haplogroup, thought to be L, all other matrilineal
haplogroups have been proven to be mutations
Using these haplogroupings to predict proclivity towards specific diseases in African Americans , though, may have disastrous effects since so many are of mixed genetic heritage.
As crazy as it might seem, White physicians don't seem to differentiate between near white-skinned Blacks and those who are very dark-skinned in making diagnoses and remedies. But even then, the dark skinned Black may not physically be the stereotypical genetic model used to treat ALL blacks. His ancestry may put him/her in a group consistent with that of a Native American or North European.
Perhaps, an awareness of this problem would be worthwhile in preventing medical mishaps due to race based medical procedures and prescriptions. And to make things worse, you get silly reports of "studies" like the one claiming "blacks" are more susceptible to HPV than whites. I guess bad news about Blacks sells better!
Since ALL humans alive today are descendants of a mitochondrial Eve from that epochal population, it would appear that all of modern humanity started out with the same Haplogroup. I am reluctant to say "L," because I don't know what the environment of East Africa was 200,000 year ago. That factor is significant since environment is thought to be the catalyst in haplogroup mutations that deviated from the original (L?) groups as modern humans left Africa.
Complicating things further is the fact that there are two distinct sets of haplogroup markers:
one originating from a common Patrilineal ancestor and the other from the matrilineal side , each with a distinct
set of letters to denote degree of mutation. From the common ancestor's mTDNA haplogroup, thought to be L, all other matrilineal
haplogroups have been proven to be mutations
Using these haplogroupings to predict proclivity towards specific diseases in African Americans , though, may have disastrous effects since so many are of mixed genetic heritage.
As crazy as it might seem, White physicians don't seem to differentiate between near white-skinned Blacks and those who are very dark-skinned in making diagnoses and remedies. But even then, the dark skinned Black may not physically be the stereotypical genetic model used to treat ALL blacks. His ancestry may put him/her in a group consistent with that of a Native American or North European.
Perhaps, an awareness of this problem would be worthwhile in preventing medical mishaps due to race based medical procedures and prescriptions. And to make things worse, you get silly reports of "studies" like the one claiming "blacks" are more susceptible to HPV than whites. I guess bad news about Blacks sells better!
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Look, it's like thinking if a dog has brown hair, then you know something about it's metabolism.
bemildred
Apr 2012
#17
But two individuals from seperate groups may require different treatments for the same disease.
hack89
Apr 2012
#35
Right, and we've been mixing them all together rapidly for the last 500 years.
bemildred
Apr 2012
#23
There is no evidence that any of those events have impacted the human genome. nt
hack89
Apr 2012
#29
I wouldn't say millions of years, more like about 100 to 50 thousand years ago when humans...
Humanist_Activist
Apr 2012
#37