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In reply to the discussion: Most cancer types 'just bad luck' [View all]jeff47
(26,549 posts)There's pretty good evidence that we actually get abnormal cells frequently. That third system is responsible for destroying those abnormal cells, and the vast majority of the time the cells are destroyed before anything interesting happens.
But the third system can not "ramp up" like the second. When we catch a cold, that second system goes from 'idle" to making tons of antibodies and cytotoxic T cells and so on - most of the stuff coming out of your nose during a cold is due to the actions of that 2nd system.
But because the third system can not "ramp up" in the same way, it's possible for the abnormal cells to grow into a tumor that the third system can not handle. That is the condition we label "cancer".
What makes these drugs interesting is they can use that 2nd system's ability to massively attack, but against tumors that the 3rd system can't handle.