Name a single movie that nearly invalidates an actor's entire career.

[ThoughtCriminal]

71. Literally killed the cast

http://en.wikipedia.org/wiki/The_Conqueror_(film)

The exterior scenes were shot on location near St. George, Utah, 137 miles (220 km) downwind of the United States government's Nevada Test Site. In 1953, extensive above-ground nuclear weapons testing occurred at the test site, as part of Operation Upshot-Knothole. The cast and crew spent many difficult weeks on location, and in addition Hughes later shipped 60 tons of dirt back to Hollywood in order to match the Utah terrain and lend verisimilitude to studio re-shoots.[4] The filmmakers knew about the nuclear tests[4] but the federal government reassured residents that the tests caused no hazard to public health.[8]

Director Dick Powell died of cancer in January 1963, seven years after the film's release. Pedro Armendáriz was diagnosed with kidney cancer in 1960, and committed suicide in 1963 after he learned his condition had become terminal. Hayward, Wayne, and Moorehead all died of cancer in the 1970s. Cast member actor John Hoyt died of lung cancer in 1991. Skeptics point to other factors such as the wide use of tobacco — Wayne and Moorehead in particular were heavy smokers. The cast and crew totaled 220 people. By 1981, 91 of them had developed some form of cancer and 46 had died of the disease. Several of Wayne and Hayward's relatives also had cancer scares as well after visiting the set. Michael Wayne developed skin cancer, his brother Patrick had a benign tumor removed from his breast and Hayward's son Tim Barker had a benign tumor removed from his mouth. [8][9]

Dr. Robert Pendleton, professor of biology at the University of Utah, stated, "With these numbers, this case could qualify as an epidemic. The connection between fallout radiation and cancer in individual cases has been practically impossible to prove conclusively. But in a group this size you'd expect only 30-some cancers to develop. With 91, I think the tie-in to their exposure on the set of The Conqueror would hold up in a court of law." Indeed, several cast and crew members, as well as relatives of those who died, considered suing the government for negligence, claiming it knew more about the hazards in the area than it let on.[8][10]