http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937226/?tool=pubmed
Expert commentary
It is apparent from this review that infant immune responses differ in many ways to adults. Assumptions from animal and adult studies have often proved inappropriate, illustrating the importance of human infant studies. Cord blood studies have demonstrated the immaturity of the immune system at birth but the difficulties and acceptability of venous blood collection make it more difficult to study infant responses. The confounders that affect responses to vaccines include prior infection, sex and nutritional status, and are particularly important in low-income settings. Understanding the mechanisms for these interactions is still limited but is of great importance to vaccine development. Indeed, it is now possible to vaccinate against many life-threatening infectious diseases.
However, the downside of this is that in particular settings the number of vaccines delivered to an infant population is extensive and include many multivalent formulations and complicated sequences of vaccines. Thus, more evidence regarding these potential interactions, and their effects on specific vaccine responses, and morbidity and mortality in general is needed. This has been a controversial area of research but is becoming more widely studied within high-infant-mortality settings.
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