GOOD NEWS! Researchers have shown Alzheimer's disease can be REVERSED- not just prevented. (Peer reviewed) [View all]

[LiberalArkie]

GOOD NEWS! Researchers have shown Alzheimer’s disease can be REVERSED- not just prevented. Using a potent neuroprotective compound called P7C3-A20, they found RESTORING balance to a central cellular energy molecule (NAD+) not only PREVENTED disease features but REVERSED them, EVEN at late stages.
In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well).
• case.edu

The study has been published in Cell. YES, it is PEER-REVIEWED.
• www.cell.com

For more than a century, Alzheimer’s disease has been framed as irreversible. Once memory and thinking decline, recovery has not been considered possible. That belief shaped nearly all research, which focused on prevention or slowing damage, not repairing it. Now, researchers from University
Hospitals, Case Western Reserve University, and the Louis Stokes Cleveland VA Medical Center report evidence that challenges this assumption. The study, published in Cell Reports Medicine, tested whether brains with advanced Alzheimer’s-like damage could recover. Using multiple mouse models and
HUMAN brain tissue, researchers found that restoring balance to a central cellular energy molecule, NAD+, not only prevented disease features but reversed them, even at late stages. The senior author, Andrew A. Pieper, MD, PhD, directs the Brain Health Medicines Center at the Harrington Discovery
Institute at University Hospitals. He also holds faculty appointments at Case Western Reserve University and serves as a clinician-scientist at the Cleveland VA. Together, the team set out to test an idea rarely explored in Alzheimer’s research: recovery.

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(This article tries to explain the article from cell.com)