Here's some info on Ibupropen I'd like to hear some comments on: [View all]

[hedgehog]

My doctor wants me to limit my ibupropen because of fear of kidney damage. Sure enough, i can point you to dozens of posting from newspapers and reputable web sites that repeat that warning. But sometimes, ibupropen is the only thing that controls my pain.

So , digging down in Google, I finally found this:

"All NSAIDs can produce a variety of adverse effects on the kidney. While there is little threat of renal insult with NSAIDs in normal, healthy individuals, risks may be increased in the elderly, in those who are dehydrated, and in those with underlying renal disease. The risk of certain types of renal toxicity may increase with the dose and duration of NSAID use.

Almost three decades of postmarketing experience with prescription-strength ibuprofen in the United States and worldwide, during which over 100 billion doses have been administered, has shown the [reporting] frequency of renal side effects to be low. Post marketing experience with non-prescription ibuprofen confirms its safety in the general population. Safety data from controlled clinical trials add further assurance that non-prescription doses of ibuprofen are well tolerated by the kidneys.

The foregoing publicly-available information has been extracted from the original Citizen’s Petition to request monograph status for ibuprofen (July 1997), and two updates (through 2001). The published OTC experience of ibuprofen during the past 18 years is consistent with a very safe profile with respect to the renal system. Despite the National Kidney Foundation’s first consensus statement published in 1984, a more recent statement in 1996, and a public FDA feedback meeting on the subject, the dire renal consequences which were forecasted with the OTC availability and use of ibuprofen have not materialized. When used as directed, the potential of OTC ibuprofen to cause renal problems is extremely low. "

http://www.fda.gov/ohrms/dockets/ac/02/briefing/3882b2_04_wyeth-ibuprophen.htm


and while the Kidney people warn against it, the Cystic Fibrosis people recommend it:

There has been some concern that ibuprofen can cause kidney damage. This can occur, but it is unlikely. Scientists know that ibuprofen decreases blood flow to the kidneys and slows down the kidneys’ ability to clear out other drugs. Your CF doctor may need to adjust the doses of other drugs you or your child are taking. Other side effects are more unusual or less severe. Ask your CF doctor about these other side effects of ibuprofen.


http://www.cff.org/treatments/Therapies/Respiratory/Ibuprofen/