as societies, we have decided that certain measurements mean certain things. if we can predict something will happen using those measurements, and if others can reproduce our results, this is a useful.
what the materialist world works with are measurements.
no doubt we are "unreliable narrators" of this world - the idea that god makes more sense when imagined by that same unreliable mind makes no sense either - rather than present an argument for god, it's an argument for nothing - because they're the same if we are unreliable narrators who can make no sense of the world.
but we do make sense of the world and reach agreements via measurements that are shared... i.e. the scientific method.
since those agreements are not reached by the working of some magical force, they can be corrected when better measurements are understood.
I didn't bother to watch the show either - the wiki summary was enough to make me say... wha? but maybe the guy has some other argument for a belief in a mind that makes things up all the time to explain the world.