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Science

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NNadir

(37,846 posts)
Mon Mar 30, 2020, 10:36 AM Mar 2020

Covid patients can remain infectious following recovery. [View all]

The paper to which I will refer is this one from scientists in China, where they have the most long term knowledge of this disease: Chang, Mo, Wang et al., Journal of Respiratory and Critical Care Medicine, https://doi.org/10.1164/rccm.202003-0524LE.

It is a small study and its statistical power is unclear, but in the interest of safety, it may be wise to consider it.

The world's scientific publishing community has made all Covid related papers open sourced, and this paper is no exception.

Time kinetics of symptom onset, duration of symptoms and viral clearance is described
in Table 1. The viral detection test was performed upon clinical presentation and repeated
every other day until the patient tested negative. The negative test was confirmed again
the next day. Upon confirmation of the negative test, the patient was asked to quarantine
at home for the next two weeks with a follow-up visit to the hospital after one week to
confirm the viral negative status. The incubation periods were estimated based on the
history of the patient’s travel or potential exposure. Our data show an incubation period
of 5 days (IQR 1-6 days) among the patients (except for patient 12 who had no specific
exposure). The mean duration of symptoms was estimated to be 8 days (IQR 6.25-11.5).
Most importantly, half (8/16) of the patient remained viral positive (a surrogate marker of

shedding) even after the resolution of symptoms (Median 2.5 days, range 1 to 8 days).
Some of our patients had other comorbidities, which included diabetes (2/16) and
tuberculosis (1/16), both of which did not affect the time course of the disease. Similarly,
the clinical course for the 3-year-old male did not significantly differ from the rest of the
patients.


Be safe and healthy.
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Ehh what? SWBTATTReg Mar 2020 #1
If someone has had Covid and has recovered from it, they can still be contagious. n/t. NNadir Mar 2020 #2
Thanks, I got this drift, it was just the article was kind of a spaghetti word salad to me...perhaps SWBTATTReg Mar 2020 #3
No problem. I'm not always very good at translating stuff to non-scientists. NNadir Mar 2020 #5
Thanks so much. A good article. Be safe and healthy. NT SWBTATTReg Mar 2020 #8
thanks for the info. Combined with the statement WhiteTara Mar 2020 #9
There seems to be an endpoint for being infectious. It is NOT forever. NNadir Mar 2020 #11
Thanks. That staying infectious AFTER getting well WhiteTara Mar 2020 #14
This was a fluke--it doesn't happen often. Igel Mar 2020 #16
Well, it's very obvious that disease syndromes with the mortality rate of Black Plague are rare. NNadir Mar 2020 #18
You said there are conditions where mutations are known to arise. defacto7 Mar 2020 #12
The mechanism by which resistance arises in bacteria, and in viruses is similar. NNadir Mar 2020 #13
you are a wealth of information WhiteTara Mar 2020 #15
Excellent explanation. defacto7 Mar 2020 #20
Have you seen anything about immunity after WhiteTara Mar 2020 #4
No, the only thing I heard is that you can get CV again, and also heard that once you have, you ... SWBTATTReg Mar 2020 #6
Perhaps those catching it again either did not fully recover yet or they caught a mutation? cstanleytech Mar 2020 #23
I just touched on this case in a response to another post. NNadir Mar 2020 #7
Good info in a pinch. defacto7 Mar 2020 #10
Still doubtful. Igel Mar 2020 #17
The state of the virus is, if you read the paper, indeterminate. NNadir Mar 2020 #19
Caution is vital Warpy Mar 2020 #22
Thanks again for all of the information, and I especially wanted to wish your sister-in-law Get ... SWBTATTReg Mar 2020 #24
Thank you so much for this Warpy Mar 2020 #21
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