49 people who were fully vaccinated have died of COVID in N.J. Here's what we know.

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56. Scientists and researchers are working on an answer to your question.

SARS-CoV-2 Variant Classifications and Definitions
Updated July 27, 2021

Laboratory studies suggest specific monoclonal antibody treatments may be less effective for treating cases of COVID-19 caused by variants with certain substitutions or combinations of substitutions in the spike protein.

L452R is present in B.1.526 (Iota), B.1.427 (Epsilon), and B.1.429 (Epsilon) lineages, as well as the B.1.617 (Kappa, Delta) lineages and sub-lineages.

E484K is present in B.1.525 (Eta), P.2 (Zeta), P.1 (Gamma), and B.1.351 (Beta), but only some strains of B.1.526 (Iota) and B.1.1.7 (Alpha).

The combination of K417N, E484K, and N501Y substitutions is present in B.1.351 (Beta).

The combination of K417T, E484K, and N501Y substitutions is present in P.1 (Gamma).

https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-info.html

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Here's one of the studies that suggests specific monoclonal antibody treatments may be less effective for treating cases of COVID-19 caused by variants with certain substitutions or combinations of substitutions in the spike protein:

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

https://www.nature.com/articles/s41586-021-03777-9#Sec23

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Here's a recent study concerning a breakthrough case:

Monoclonal Antibody Therapy in a Vaccine Breakthrough SARS-CoV-2 Hospitalized Delta (B.1.617.2) Variant Case

https://www.sciencedirect.com/science/article/pii/S1201971221005865