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RainDog

(28,784 posts)
54. Michael Backes of Abatin Wellness Center says...
Sat May 10, 2014, 06:53 AM
May 2014

and I can only quote, not respond as someone with direct knowledge (but Backes is very involved with cannabis-based MS medicine and very science-based, not anecdote-based, in response to the doctor who has talked about juicing...

Courtney's claim that raw cannabis is not psychoactive is true, but only for pristine, fresh cannabis. Disturb the gland heads on a living cannabis plant of a strain that contains THC and the process of converting its non-psychoactive THCA to psychoactive THC begins, albeit slowly.

...if someone is not harvesting the cannabis fresh and consuming it immediately, then there is a risk of significant THC intoxication.


...so he says raw cannabis THC is not as available as when it's already been chemically activated by heat extraction, it seems.

beyond that, it's interesting that, upon heating, THCA decarboxylates to THC - if this is done by smoke, the effect is immediate. If this is done by cooking/ingestion, the effect takes up to an hour - and the intoxication is different because, in the liver, delta-9-tetrahydracannabinol is metabolized into 11-hydroxy-tetrahydracannabinol (a metabolite), while smoking converts THCA into delta-9 and acts directly on the nervous system without liver metabolization - tho, immediately after smoking, THC, too, begins conversion to 11-THC as a metabolites in the bloodstream - which is noticeable an hour after, just as eaten cannabis takes about an hour to take effect. 11-THC is further broken down to the non-psychoactive 11-COOH-THC - which is the metabolite that stays in the body for days or weeks as it is slowly excreted - and this is the metabolite that identifies marijuana use in urine tests.

11-COOH-THC also mediates the effects of THC itself - which is one possible explanation for differences in intoxication between heavy/long time users and those who use cannabis infrequently - iow - the reason people feel higher if they use less often is because their body does not contain the metabolite 11-COOH-THC to dampen the effect of THC itself. This slow release (and dampening effect) is also why THC does not act upon people in the way something like heroin does - physiologically, cannabis provides its own "weaning" - unlike drugs of addiction - while the psychological desire would have to do with the pleasure of the effect of THC, but not, again, from a physical impulse - but the psychological desire would have lesser returns with more use, so there's no reward for such desire through increased use - and, in fact, such reward would be thwarted by constant use.

(This may also explain why those who are heavier users of THC are better drivers than those who use cannabis infrequently.)

At low levels, 11-THC produces drowsiness/a good night's sleep. At high levels, 11-THC can produce hallucinations. It's more likely that eating would produce these high levels because people are more likely to eat larger doses because they can't titrate as accurately as they can with smoked cannabis.

As a metabolite - 11-COOH-THC continues some anti-inflammatory action in the body

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I personally think it was brussel sprouts... Egnever May 2014 #1
Some entertain the idea it may have been Lima beans.... Brother Buzz May 2014 #9
I bow to your wisdom Brother Buzz Egnever May 2014 #19
technically, it's "brussels sprouts". but perhaps in biblical times there was only one brussel. unblock May 2014 #10
Maybe it was a road apple. geomon666 May 2014 #2
Poppies. TreasonousBastard May 2014 #3
they would have had to known how make a butter reduction to render the THC from the buds, dionysus May 2014 #4
You can eat the buds. MohRokTah May 2014 #5
really? i munched a few buds once and didnt notice anything. i thought you needed heat to render the dionysus May 2014 #8
Nope. THC does not require the heat. MohRokTah May 2014 #11
i ate about a 2 bowls worth of dank, i didn't notice much, but the rice crispy treats i tried. OMFG! dionysus May 2014 #13
The active chemicals in both the dank you ate and the rice crispy treats was identical. MohRokTah May 2014 #15
I'm not persuaded jberryhill May 2014 #30
The bioavailability is much higher when properly prepared in a fatty oil. Taitertots May 2014 #34
The ecig folks have been busy too jberryhill May 2014 #42
I have done the work MohRokTah May 2014 #43
Nope, the chemical enters your bloodstream identically both ways. MohRokTah May 2014 #35
Oh, you're killing me jberryhill May 2014 #44
interesting, thank you. dionysus May 2014 #47
You do jmowreader May 2014 #64
Pot salad will do almost nothing Taitertots May 2014 #16
Then you've never eaten it. MohRokTah May 2014 #17
Hmm but juicing changes that? Egnever May 2014 #21
Nope, same chemical composition. MohRokTah May 2014 #23
I tried many things in the foolhardy days of my youth. Taitertots May 2014 #22
You are incorrect. MohRokTah May 2014 #24
Try it for yourself. Smoke a gram, eat a gram, make a gram into fat based cookies Taitertots May 2014 #29
I've done all three, many many times MohRokTah May 2014 #31
You are missing the point jberryhill May 2014 #37
No, precisely ZERO extraction from vegetative material has been done for you. MohRokTah May 2014 #40
It's not about heat jberryhill May 2014 #32
Liposolubility is not a factor in digestive ingestion. eom MohRokTah May 2014 #36
Transport. Fluid transport. jberryhill May 2014 #38
Again, liposolubility is not a factor in digestive ingestion. eom MohRokTah May 2014 #41
Michael Backes of Abatin Wellness Center says... RainDog May 2014 #54
It's not about heat jberryhill May 2014 #32
This IS the FSM we are talking about here right? VanillaRhapsody May 2014 #6
There is no god, Go Vols May 2014 #7
Then there was the legend of Johnny Ganjaseed... TexasTowelie May 2014 #12
so god rips out adam's rib to make eve. adam needed some medicine asap nt msongs May 2014 #14
Peyote, dude. McCamy Taylor May 2014 #18
It was the magic mushroom, of course. Comrade Grumpy May 2014 #20
In 1000 years they will find remains of the apple snow white bit into. n/t 951-Riverside May 2014 #25
This message was self-deleted by its author lunasun May 2014 #26
Figs? trusty elf May 2014 #27
"Madam, I'm Adam" KansDem May 2014 #51
The first or the second. Depends on who hit on whom first. GreatCaesarsGhost May 2014 #59
mmm-hmmm trusty elf May 2014 #60
I didn't know pot grew on trees. ohheckyeah May 2014 #28
Yes, but... jberryhill May 2014 #39
This message was self-deleted by its author Warren DeMontague May 2014 #45
The "Forbidden Fruit" was from the "Tree of Knowledge". Adam and Eve were kept in the "Garden Ghost in the Machine May 2014 #46
I've always read the Serpent as a hero in the story Scootaloo May 2014 #48
"I've always really, really sucked at being a Christian. I tried, i tried really, really hard. it Ghost in the Machine May 2014 #53
Christianity, aka Paul, turned ancient religion/wisdom on its head, demonizing women and the WinkyDink May 2014 #56
It was a feature well before Paul Scootaloo May 2014 #61
Haha! True enough! I conflated modernity with monotheism! WinkyDink May 2014 #63
That's one of the first things that turned me off xtianity too RainDog May 2014 #58
Seeing that the story of Adam and Eve is nothing more than a fairy tale the forbidden fruit can be Exposethefrauds May 2014 #49
One linguist said cannabis is kaneh bosm in the OT RainDog May 2014 #50
+1 eShirl May 2014 #65
So I've been smoking "Trees Of Knowledge"? Motown_Johnny May 2014 #52
He seems not even to know that it was knowledge that was promised. WinkyDink May 2014 #55
According to the story Adam and Eve did not have kids till they were kicked out Exposethefrauds May 2014 #57
How do you identify a fruit mentioned in a fable? MineralMan May 2014 #62
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